If you're not using roaming profiles or some sort of offline sync/backup you will want to make sure all your data is preserved (Docs, pics, desktop, etc). To answer your question when you go to advanced system settings and delete a profile it will remove ALL data associated with that profile. This will give you a "clean" install again without having to use CC cleaner. It will also find programs that were previously installed but removed from the control panel. It looks to the registry, uninstalls the program and cleans the registry at the same time. I get the offline version and save it for when its needed. On top of what everyone has said above (checking event logs, isolating the issue, different users, different profiles, different machines) I've also had good results using the microsoft uninstaller "fix it" tool. Good luck and keep us informed about the progress and if you get to a resolution. I took a casual read through this and I think that this might be able to assist in resolving the problems for you. There is a great article here from MS regarding improving Excel 2010 performance: Using Office 64 Bit is an option, but we could never get it to work properly for us, and that may be my own personal limitations rather than Office itself. On my own work system I've had to increase the memory allocation to word for the very same reason, and since doing so have stopped the hang-ups, freezes and crashes to a large extent. What I've found is that excel 32 bit users with large spreadsheets usually have issues because of the memory size limitations imposed on Office products natively. If the size of the profile is over the 1 Gb mark, then you have some issues. Check the size of the user profile - smaller is better.Click the settings button in User Profiles.I'll assume 7 (I know that assumption is the mother of all fowl ups, but I have to start somewhere) Here are a few things to check in the system properties before you go haring off to delete user profiles:
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